Lab Members

bibliography-man

Antonio Bertoletti, M.D.

Professor,
Duke-NUS Graduate Medical School

Division Emerging Infectious Diseases, Singapore
Tel: + 65 6601 3574
Fax: + 65 6772 4112
Email: antonio@duke-nus.edu.sg
Skype: bertolettiaa

I trained as a specialist in Infectious Diseases and I have always been interested in the immunological control of persistent viral infections, particularly Hepatitis B (HBV).

During my research career, first in USA (The Scripps Research Institute) and then in Italy (University of Parma), I was the first to characterize hepatitis B virus (HBV)–specific human CD8 T cells in HBV infected patients (Proc. Natl. Acad. Sci. USA 1991 88: 10445), and to define the effect of HBV mutations in HBV-specific CTL function (Nature 1994 369: 407-J. Exp. Med. 1994 180: 933)

I moved to London (University College of London) in 1997, where I pioneered the use of HLA-tetramers in HBV infected subjects and used them to characterize the role of HBV-specific T cells in viral control and disease pathogenesis (J. Exp. Med. 2000, 191: 1269 ,J. Exp. Med, 2002 195: 1089; J. Virol, 2004, 78;5707)

In 2006 I moved to Singapore, motivated by the opportunity to build on our understanding of HBV infection, a worldwide serious health problem that is over-represented in Asia and I became Director of Infection and Immunity Program at the Singapore Institute for Clinical Sciences (A*STAR) until 2013, after which I joined as a Professor in the Emerging Infectious Disease Programme at Duke-NUS Graduate Medical School in the same year.

In my laboratory we characterized the impact of Asian HLA- class I profile and HBV genotypes on on HBV immunopathogenesis (J. Virol. 2008 82: 10986, Gastroenterology 2012, 43 :637; J Clin Invest. 2013 123(9):3766). Our current research focuses on the development of new immunological based therapies (TCR-redirected T cells, HLA-peptide specific antibodies) for the treatment of HBV and Hepatocellular carcinoma (HCC), and the characterization of human intra-sinusoidal hepatic immune system.

Positions

  1. 1987-1989 Resident in the Department of Infectious Diseases, University of Parma, Italy
  2. 1989-1991 Research fellow in the laboratory of Dr. Frank Chisari, Scripps Research Institute
  3. 1991-1996 Assistant, Department of Infectious Diseases, Main Hospital of Parma, Parma, Italy
  4. 1996-1997 Senior Immunologist, MRC Laboratories, Fajara, The Gambia
  5. 1998-2001 Senior Lecturer in Medicine, Institute of Hepatology, UCLMS, London
  6. 2001-2006 Reader in Experimental Hepatology, Institute of Hepatology, UCLMS, London.
  7. 2006-2008 Principal Investigator, Singapore Institute Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore
  8. 2008-2013 Director Infection and Immunity Program, SICS, A*STAR, Singapore
  9. 2013-present Professor, Program of Emerging Viral Diseases, Duke-Nus Medical School, Singapore
  10. 2013-present Research Director, Viral Hepatitis Unit, Singapore Institute for Clinical Science, A*STAR, Singapore
Laura

Laura Rivino
Assistant Professor
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Anthony

Anthony Tan
Senior Research Fellow
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Atefeh

Atefeh Khakpoor
Research Fellow
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Michelle

Michelle Hong
Research Fellow
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Nina

Nina Le Bert
Research Fellow
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Ninghan

Yang Ninghan
Research Fellow
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Adeline

Adeline Chia
Research Associate
(Senior)
Lu

Lu Siyan
Research Assistant
(Senior)
Kamini

Kamini Kunasegaran
Research Assistant
Damien

Reshmi Giri
Research Assistant
Damien

Vincent Oei
Research Assistant
Alfonso

Alfonso Tan Garcia
MD-PhD Student
Christine

Christine Tham
PhD Student
Erica

Erica Ceccarello
PhD Student
Loghman-Salim

Loghman Salimdazeh
PhD Student