Chronic hepatitis B virus (HBV) infection affecting more than 350 million worldwide can lead to sever liver diseases including cirrhosis and hepatocellular carcinoma (HCC). In our research projects we are employing different techniques to answer critical questions on virology aspect of HBV infection. One interesting question to answer is how virus production, replication and viral mRNA kinetics might be affected or may affect the immune response to HBV infection using our infection system.
On another aspect, we aim to answer one controversial question on the differences between tumor and Adjacent non-tumor regions in HBV-HCC patients in terms of presence or absence of virus replication or viral antigen presentation levels.
Yang Ning Han